Changes in hepatitis B virus surface antibody titer and risk of hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients undergoing biologic therapy for rheumatic diseases: a prospective cohort study.

ABSTRACT:

Background

Our aim was to investigate dynamic changes in hepatitis B virus (HBV) surface antibody (HBsAb) titer and the associated risk of HBV reactivation and clinical course in patients with HBV surface antigen negative/core antibody positive (HBsAg^-/HBcAb⁺) serostatus during antirheumatic therapy with biologic agents.

Methods

In a prospective study from January 2013 to June 2017, we monitored the HBV serostatus of HBsAg^-/HBcAb⁺ patients undergoing biologic therapy for rheumatic diseases. From HBsAb titers at baseline and subsequent time points, we calculated the person-years (PY) contributed by patients with different HBsAb levels: < 10 mIU/mL (negative); 10-100 mIU/mL (low); and > 100 mIU/mL (high). We analyzed the incidence of

SUBMITTER: Tien YC 

PROVIDER: S-EPMC6235201 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature