Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis.

ABSTRACT:

Background

Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD) is a life-threatening condition. Serum cytokine levels are potentially suitable biomarkers for DM RP-ILD. However, the relationships among cytokine levels, lung imaging findings, and lung pathology have not been investigated. The aim of the present retrospective study was to determine the association between hypercytokinemia and lung inflammation in patients with DM RP-ILD.

Methods

The study subjects were nine patients with life-threatening DM RP-ILD and severe hypoxemia (partial arterial oxygen pressure (PaO₂)/fraction of inspired oxygen (FiO₂) ratio ≤ 200) before receiving intensive care management, who were admitted to our hospital between 2006 and 2015. Th

SUBMITTER: Ishikawa Y 

PROVIDER: S-EPMC6235206 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature