The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation.

ABSTRACT:

Background

Gut microbiota alterations are important in irritable bowel syndrome (IBS). The aim was to investigate the effect of fecal microbiota transplantation (FMT) on gut microbiota and the symptoms in patients with IBS.

Material and methods

The study included 13 IBS patients according to Rome III criteria and 13 healthy donors. Freshly donated feces were administered to the descending part of the duodenum via a gastroscope. Feces were collected from donors and patients before FMT, and from the patients at 1, 3 and 12 weeks and donors and patients at 20/28 weeks after FMT. Microbiota analysis was performed using GA-map Dysbiosis test (Genetic Analysis AS, Oslo, Norway). The patients completed the following questionnaires before and at the aforementioned weeks after FMT: I

SUBMITTER: Mazzawi T 

PROVIDER: S-EPMC6235238 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature