Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish.

ABSTRACT: Mycobacterium tuberculosis is currently the deadliest human pathogen causing 1.7 million deaths and 10.4 million infections every year. Exposure to this bacterium causes a wide disease spectrum in humans ranging from a sterilized infection to an actively progressing deadly disease. The most common form is the latent tuberculosis, which is asymptomatic, but has the potential to reactivate into a fulminant disease. Adult zebrafish and its natural pathogen Mycobacterium marinum have recently proven to be an applicable model to study the wide disease spectrum of tuberculosis. Importantly, spontaneous latency and reactivation as well as adaptive immune responses in the context of mycobacterial infection can be studied in this model. In this article, we describe methods for the experimental infe

SUBMITTER: Luukinen H 

PROVIDER: S-EPMC6235461 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature