Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production.

ABSTRACT: The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes. However, the increasing number of different tracers creates challenges for their production at radiopharmacies. While historically it has been practical to dedicate a custom-configured radiosynthesizer and hot cell for the repeated production of each individual tracer, it is becoming necessary to change this workflow. Recent commercial radiosynthesizers based on disposable cassettes/kits for each tracer simplify the production of multiple tracers with one set of equipment by eliminating the need for custom tracer-specific modifications. Furthermore, some of these radiosynthesizers enable the operator to develop and

SUBMITTER: Schopf E 

PROVIDER: S-EPMC6235612 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature