Lifetime Smoking History and Risk of Lung Cancer: Results From the Framingham Heart Study.

ABSTRACT:

Background

The relative risk of lung cancer decreases with years since quitting (YSQ) smoking, but risk beyond 25 YSQ remains unclear. Current lung cancer screening guidelines, which exclude smokers with more than 15 YSQ, may not detect lung cancers in this population.

Methods

We analyzed data from Framingham Heart Study Original (n = 3905) and Offspring cohort (n = 5002) participants for lifetime smoking and lung cancer incidence from 1954 to 1958 (Exam 4) and 1971 to 1975 (Exam 1), respectively, through 2013. We used multivariable-adjusted Cox proportional hazards regression models to compare current, former, and never smokers and lung cancer risk. Smoking status and covariates were time-updated every two years (Original) or four years (Offspring). Primary analyses were re

SUBMITTER: Tindle HA 

PROVIDER: S-EPMC6235683 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature