The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes.

ABSTRACT:

Background

This study investigated the effects of metformin and weight loss on biomarkers associated with breast cancer prognosis.

Methods

Overweight/obese postmenopausal breast cancer survivors (n = 333) were randomly assigned to metformin vs placebo and to a weight loss intervention vs control (ie, usual care). The 2 × 2 factorial design allows a single randomized trial to investigate the effect of two factors and interactions between them. Outcomes were changes in fasting insulin, glucose, C-reactive protein (CRP), estradiol, testosterone, and sex-hormone binding globulin (SHBG). The trial was powered for a main effects analysis of metformin vs placebo and weight loss vs control. All tests of statistical significance were two-sided.

Results

A total of 313 women (94

SUBMITTER: Patterson RE 

PROVIDER: S-EPMC6235688 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature