Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study.

ABSTRACT:

Objective

To examine rest-activity circadian rhythm (RAR) and cognitive decline in older men.

Design

Longitudinal.

Setting

Osteoporotic Fractures in Men (MrOS) and ancillary Outcomes of Sleep Disorders in Men (MrOS Sleep) studies.

Participants

MrOS and MrOS Sleep participants (N=2,754; mean age 76.0 ± 5.3).

Measurements

The Modified Mini-Mental State examination (3MS) was used to assess cognition at baseline (2003-05) and follow-up examinations (2005-06 and 2007-09). Wrist actigraphy was used to measure 24-hour activity counts at baseline. RAR variables included amplitude (strength of activity rhythm), mesor (mean activity level), pseudo F-statistic (overall circadian rhythm robustness), and acrophase (time of daily peak activity).

Results

After a

SUBMITTER: Rogers-Soeder TS 

PROVIDER: S-EPMC6235690 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature