Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein.

ABSTRACT: Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC bio

SUBMITTER: Sharif R 

PROVIDER: S-EPMC6235698 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature