NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies.

ABSTRACT: Retinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. However, despite this diversity, many of these diseases share a common endpoint involving death of light-sensitive photoreceptors. Identifying common pathogenic mechanisms that contribute to photoreceptor death in these diverse diseases may lead to a unifying therapy for multiple retinal diseases that would be highly innovative and address a great clinical need. Because the retina and photoreceptors, in particular, have immense metabolic and energetic requirements, many investigators have hypothesized that metabolic dys

SUBMITTER: Lin JB 

PROVIDER: S-EPMC6235699 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature