Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.

ABSTRACT: Smoking is the leading cause of preventable death worldwide. Though cigarette smoke is an established cause of head and neck cancer (including oral cancer), molecular alterations associated with chronic cigarette smoke exposure are poorly studied. To understand the signaling alterations induced by chronic exposure to cigarette smoke, we developed a cell line model by exposing normal oral keratinocytes to cigarette smoke for a period of 12 months. Chronic exposure to cigarette smoke resulted in increased cellular proliferation and invasive ability of oral keratinocytes. Proteomic and phosphoproteomic analyses showed dysregulation of several proteins involved in cellular movement and cytoskeletal reorganization in smoke exposed cells. We observed overexpression and hyperphosphorylation of pr

SUBMITTER: Rajagopalan P 

PROVIDER: S-EPMC6235782 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature