Effects of renal denervation on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats.

ABSTRACT:

Purpose

Renal denervation (RD) has been demonstrated to be an effective approach to reduce blood pressure for those with resistant hypertension. Yet, we aimed to explore the effect and possible mechanism of RD on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats.

Methods

A total of 48 male spontaneously hypertensive rats were randomized to three groups: study group, sham-operation group and control group. RD was achieved by cutting off renal nerves and swabbing phenol on it. Ten weeks after RD, 8 rats in each group were sacrificed to collect the kidney and heart tissues. The remaining rats were subjected to an operation to induce hemorrhagic shock which would lead to 40% loss of total blood volume, and observed for 120 min. The serum concentrati

SUBMITTER: Cai XN 

PROVIDER: S-EPMC6235792 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature