Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.

ABSTRACT:

Aims

Sepsis-caused multiple organ failure remains the major cause of morbidity and mortality in intensive care units. Nicotinamide riboside (NR) is a precursor of nicotinamide adenine dinucleotide (NAD⁺), which is important in regulating oxidative stress. This study investigated whether administration of NR prevented oxidative stress and organ injury in sepsis.

Methods

Mouse sepsis models were induced by injection of lipopolysaccharides (LPS) or feces-injection-in-peritoneum. NR was given before sepsis onset. Cultured macrophages and endothelial cells were incubated with various agents.

Results

Administration of NR elevated the NAD⁺ levels, and elicited a reduction of oxidative stress, inflammation and caspase-3 activity in lung and heart tissues

SUBMITTER: Hong G 

PROVIDER: S-EPMC6236680 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature