Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein.

ABSTRACT: Viruses utilize a number of host factors in order to carry out their replication cycles. Influenza A virus (IAV) and human respiratory syncytial virus (RSV) both infect the tissues of the respiratory tract, and as such we hypothesize that they might require similar host factors. Several published genome-wide screens have identified putative IAV host factors; however, there is significant discordance between their hits. In order to build on this work, we integrated a variety of "OMICS" data sources using two complementary network analyses, yielding 51 genes enriched for both IAV and RSV replication. We designed a targeted small interfering RNA (siRNA)-based assay to screen these genes against IAV under robust conditions and identified 13 genes supported by two IAV subtypes in both primary a

SUBMITTER: Beyleveld G 

PROVIDER: S-EPMC6236804 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature