Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases.

ABSTRACT: Metastasis is the most common cause of death for patients with cancer. To fully understand the steps involved in metastatic dissemination, in vivo models are required, of which murine ones are the most common. Therefore, preclinical imaging methods such as magnetic resonance imaging (MRI) have mainly been developed for small mammals and their potential to monitor cancer growth and metastasis in nonmammalian models is not fully harnessed. We have here used MRI to measure primary neuroblastoma tumor size and metastasis in a chick embryo model. We compared its sensitivity and accuracy to end-point fluorescence detection upon dissection. Human neuroblastoma cells labeled with green fluorescent protein (GFP) and micron-sized iron particles were implanted on the extraembryonic chorioallantoic me

SUBMITTER: Herrmann A 

PROVIDER: S-EPMC6236852 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature