Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice.
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ABSTRACT:
SUBMITTER: Murtaza G
PROVIDER: S-EPMC6236867 | biostudies-literature | 2018 Oct-Dec
REPOSITORIES: biostudies-literature
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Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice.
Murtaza Ghulam G Paddenberg Renate R Pfeil Uwe U Goldenberg Anna A Mermer Petra P Kummer Wolfgang W
Pulmonary circulation 20181004 4
We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25-40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level. ...[more]
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