Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development.

ABSTRACT: Survival and cell death signals are crucial for mammalian embryo preimplantation development. However, the knowledge on the molecular mechanisms underlying their regulation is still limited. Mouse studies are widely used to understand preimplantation embryo development, but extrapolation of these results to humans is questionable. Therefore, we wanted to analyse the global expression profiles during early mouse and human development with a special focus on genes involved in the regulation of the apoptotic and survival pathways. We used DNA microarray technology to analyse the global gene expression profiles of preimplantation human and mouse embryos (metaphase II oocytes, embryos at the embryonic genome activation stage, and blastocysts). Components of the major apoptotic and survival sign

SUBMITTER: Haouzi D 

PROVIDER: S-EPMC6236930 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature