Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson's Disease: A Pilot Study.

ABSTRACT:

Background

Sleep problems in patients with advanced Parkinson's disease (PD) have a deleterious impact on quality of life.

Objective

To assess the effect of levodopa-carbidopa intestinal gel (LCIG) infusion on sleep quality in advanced PD patients.

Methods

Seven patients participated in a prospective pilot study. Before and after 6 months of LCIG infusion, an overnight polysomnography was performed and the Epworth Sleepiness Scale, fatigue scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, and the Hamilton Anxiety Rating Scale were administered.

Results

PSG showed low sleep efficiency. REM sleep without atony was found in 5 patients. After 6 months of LCIG infusion, the percentage of REM sleep decreased as well as the number of arousals especiall

SUBMITTER: De Fabregues O 

PROVIDER: S-EPMC6236977 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature