Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.

ABSTRACT:

Background

Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain controversial.

Methods

Concentrations of serum TNF-α of 147 patients with IgAN and 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations with clinicopathological features of patients with IgAN were evaluated.

Results

Serum levels of TNF-α [9.20 (7.70-10.60) pg/mL vs. 6.04 (5.11-7.23) pg/mL, P < 0.0001] were higher in patients with IgAN than that in healthy subjects. Receiver operating characteristic curve analysis revealed that TNF-α had better discrimination between patients with IgAN and healthy controls than estimated gl

SUBMITTER: Li G 

PROVIDER: S-EPMC6236996 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature