Kidney Function Reserve Capacity in Early and Later Stage Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT:

Background and objectives

It is assumed that in autosomal dominant polycystic kidney disease (ADPKD), kidney function remains in the normal range for several decades because of hyperfiltration of remnant nephrons. In this study, we investigate the extent to which patients with ADPKD hyperfilter.

Design, setting, participants, & measurements

In this cross-sectional study, we measured GFR as urinary clearance using continuous infusion of ¹²⁵I-iothalamate. Kidney function reserve capacity was determined as increase in measured GFR after adding a dopamine infusion of 4.4-6 mg/h. Potential kidney donors were used as healthy controls and matched by age and sex to patients with ADPKD for comparisons across age groups and CKD stages. Hyperfiltration was defined by a loss

SUBMITTER: Messchendorp AL 

PROVIDER: S-EPMC6237049 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature