CKD in Patients with Bilateral Oophorectomy.

ABSTRACT:

Background and objectives

Premenopausal women who undergo bilateral oophorectomy are at a higher risk of morbidity and mortality. Given the potential benefits of estrogen on kidney function, we hypothesized that women who undergo bilateral oophorectomy are at higher risk of CKD.

Design, setting, participants, & measurements

We performed a population-based cohort study of 1653 women residing in Olmsted County, Minnesota who underwent bilateral oophorectomy before age 50 years old and before the onset of menopause from 1988 to 2007. These women were matched by age (±1 year) to 1653 referent women who did not undergo oophorectomy. Women were followed over a median of 14 years to assess the incidence of CKD. CKD was primarily defined using eGFR (eGFR<60 ml/min per 1.73 m^2</

SUBMITTER: Kattah AG 

PROVIDER: S-EPMC6237067 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature