Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins.

ABSTRACT: A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.

SUBMITTER: Sedgwick DM 

PROVIDER: S-EPMC6237092 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature