Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria.

ABSTRACT: The proteins responsible for controlling electron transfer in bacterial secondary metabolism are not always known or characterised. Here we demonstrate that many bacteria contain a set of unfamiliar ferredoxin encoding genes which are associated with those of cytochrome P450 (CYP) monooxygenases and as such are involved in anabolic and catabolic metabolism. The model organism Mycobacterium marinum M contains eleven of these genes which encode [3Fe-4S] or [4Fe-4S] single cluster containing ferredoxins but which have unusual iron-sulfur cluster binding motif sequences, CXX?XXC(X) _n CP, where '?' indicates a variable amino acid residue. Rather than a cysteine residue, which is highly conserved in [4Fe-4S] clusters, or alanine or glyc

SUBMITTER: Child SA 

PROVIDER: S-EPMC6237146 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature