Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway.

ABSTRACT:

Context

Ma Huang Tang (MHT) has been used to treat influenza, fever, bronchial asthma, etc. as a traditional Chinese medication. However, the anti-inflammation mechanism of MHT remains unclear.

Objective

The study identifies the possible mechanisms of MHT on ovalbumin (OVA)-induced acute bronchial asthma in mice.

Materials and methods

First, an asthma-related protein-protein interaction (PPI) network was constructed. And then, the acute bronchial asthma mice models were established by exposing to aerosolized 1% ovalbumin for 30 min/day for 1 week, and the mice were administered 2.0, 4.0, or 8.0 g/kg of MHT daily. To evaluate therapeutic effect, sensitization time, abdominal breathing time, eosinophils in bronchoalveolar lavage fluid, and tissue and trachea pathology w

SUBMITTER: Jiao J 

PROVIDER: S-EPMC6237163 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature