Non-Hodgkin lymphoma risk in adults living with HIV across five continents.

ABSTRACT:

Objective

To compare non-Hodgkin lymphoma (NHL) incidence rates in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.

Methods

We included cohort data of adults living with HIV who started ART after 1995 within the framework of the International epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE). We used flexible parametric survival models to compare regional NHL rates at 2 years after ART start and to identify risk factors for NHL.

Results

We included 210 898 adults with 1.1 million person-years (pys) of follow-up and 1552 incident NHL cases (raw overall incidence rate 142/100 000 pys). After adjusting for age at ART

SUBMITTER: AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord 

PROVIDER: S-EPMC6237186 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature