Evidence That Rat Chondrocytes Can Differentiate Into Perichondrial Cells.

ABSTRACT: During early bone formation, mesenchymal cells condense and then differentiate into collagen type II-expressing chondrocytes that make up the cartilaginous bone anlagen. This anlage then becomes enclosed by the perichondrium. The mechanisms by which the perichondrium forms are not known. The purpose of this study was to determine whether epiphyseal chondrocytes can differentiate into perichondrial cells. Novel perichondrium markers were identified by expression microarray of microdissected rat perichondrium and growth plate cartilage. A dissection method that allowed for removal of contaminating perichondrium was developed and the absence was confirmed by histological examination and by expression of perichondrium markers. Perichondrium formation surrounding chondrocyte pellets was studied

SUBMITTER: Spath SS 

PROVIDER: S-EPMC6237212 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature