Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

ABSTRACT:

Background

Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the clinical onset, is not well understood. We previously reported that the number of circulating neutrophils is reduced in patients with T1D and in presymptomatic at-risk subjects. The aim of the present work was to identify possible changes in circulating and pancreas-residing neutrophils throughout the disease course to better elucidate neutrophil involvement in human T1D.

Methods

Data collected from 389 subjects at risk of developing T1D, and enrolled in 4 distinct studies performed by TrialNet, were analyzed with comprehensive sta

SUBMITTER: Vecchio F 

PROVIDER: S-EPMC6237216 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature