Aerosol-synthesized siliceous nanoparticles: impact of morphology and functionalization on biodistribution.

ABSTRACT:

Introduction

Siliceous nanoparticles (NPs) have been extensively studied in nanomedicine due to their high biocompatibility and immense biomedical potential. Although numerous technologies have been developed, the synthesis of siliceous NPs for biomedical applications mainly relies on a few core technologies predominantly intended to produce spherical-shaped NPs.

Methods

In this context, the impact of different morphologies of siliceous NPs on biodistribution in vivo is limited. In the present study, we developed a novel technique based on an aerosol silane reactor to produce sintered silicon NPs of similar size but different surface areas due to distinct spherical subunits. Silica-converted particles were functionalized for radiolabeling with copper-64 (⁶⁴Cu) to

SUBMITTER: Diebolder P 

PROVIDER: S-EPMC6237247 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature