Ontology highlight
ABSTRACT:
SUBMITTER: Schneider S
PROVIDER: S-EPMC6237357 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Schneider Sandra S Hotaling Nathan N Campos Maria M Patnaik Sarita Rani SR Bharti Kapil K May-Simera Helen Louise HL
PloS one 20181115 11
The retinal pigment epithelium (RPE) is an epithelial monolayer in the back of the vertebrate eye. RPE dysfunction is associated with retinal degeneration and blindness. In order to fully understand how dysregulation affects visual function, RPE-specific gene knockouts are indispensable. Since the currently available RPE-specific Cre recombinases show lack of specificity or poor recombination, we sought to generate an alternative. We generated a tamoxifen-inducible RPE-specific Cre transgenic mo ...[more]