Ontology highlight
ABSTRACT:
SUBMITTER: Poe JC
PROVIDER: S-EPMC6237454 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
JCI insight 20181004 19
Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute and chronic GVHD development, making it an attractive target for GVHD prevention. Entospletinib (ENTO) is a second-generation highly selective SYK inhibitor with a high safety profile. Potential utility of ENTO as GVHD prophylaxis in patients was examined using a preclinical mouse model of eye and skin GVHD and ENTO-compounded chow. We found ...[more]