Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

ABSTRACT:

Background

Resting brain connectivity is a crucial component of human behavior demonstrated by disruptions in psychosexual and emotional disorders. Kisspeptin, a recently identified critical reproductive hormone, can alter activity in certain brain structures but its effects on resting brain connectivity and networks in humans remain elusive.

Methods

We determined the effects of kisspeptin on resting brain connectivity (using functional neuroimaging) and behavior (using psychometric analyses) in healthy men, in a randomized double-blinded 2-way placebo-controlled study.

Results

Kisspeptin's modulation of the default mode network (DMN) correlated with increased limbic activity in response to sexual stimuli (globus pallidus r = 0.500, P = 0.005; cingulate r = 0.475, P =

SUBMITTER: Comninos AN 

PROVIDER: S-EPMC6237465 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature