Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design.

ABSTRACT: HIV eradication studies have focused on developing latency-reversing agents (LRAs). However, it is not understood how the rate of latent reservoir reduction is affected by different steps in the process of latency reversal. Furthermore, as current LRAs are host-directed, LRA treatment is likely to be intermittent to avoid host toxicities. Few careful studies of the serial effects of pulsatile LRA treatment have yet been done. This lack of clarity makes it difficult to evaluate the efficacy of candidate LRAs or predict long-term treatment outcomes. We constructed a mathematical model that describes the dynamics of latently infected cells under LRA treatment. Model analysis showed that, in addition to increasing the immune recognition and clearance of infected cells, the duration of HIV anti

SUBMITTER: Ke R 

PROVIDER: S-EPMC6237475 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature