Ontology highlight
ABSTRACT:
SUBMITTER: Ordikhani F
PROVIDER: S-EPMC6237477 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Ordikhani Farideh F Uehara Mayuko M Kasinath Vivek V Dai Li L Eskandari Siawosh K SK Bahmani Baharak B Yonar Merve M Azzi Jamil R JR Haik Yousef Y Sage Peter T PT Murphy George F GF Annabi Nasim N Schatton Tobias T Guleria Indira I Abdi Reza R
JCI insight 20181018 20
Recent studies in cancer research have focused intensely on the antineoplastic effects of immune checkpoint inhibitors. While the development of these inhibitors has progressed successfully, strategies to further improve their efficacy and reduce their toxicity are still needed. We hypothesized that the delivery of anti-PD-1 antibody encapsulated in PLGA nanoparticles (anti-PD-1 NPs) to the spleen would improve the antitumor effect of this agent. Unexpectedly, we found that mice treated with a h ...[more]