Glucose metabolism controls disease-specific signatures of macrophage effector functions.

ABSTRACT:

Background

In inflammatory blood vessel diseases, macrophages represent a key component of the vascular infiltrates and are responsible for tissue injury and wall remodeling.

Methods

To examine whether inflammatory macrophages in the vessel wall display a single distinctive effector program, we compared functional profiles in patients with either coronary artery disease (CAD) or giant cell arteritis (GCA).

Results

Unexpectedly, monocyte-derived macrophages from the 2 patient cohorts displayed disease-specific signatures and differed fundamentally in metabolic fitness. Macrophages from CAD patients were high producers for T cell chemoattractants (CXCL9, CXCL10), the cytokines IL-1β and IL-6, and the immunoinhibitory ligand PD-L1. In contrast, macrophages from GCA patie

SUBMITTER: Watanabe R 

PROVIDER: S-EPMC6237479 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature