What Can Be Done to Improve Research Biopsy Quality in Oncology Clinical Trials?

ABSTRACT:

Purpose:

Research biopsy specimens collected in clinical trials often present requirements beyond those of tumor biopsy specimens collected for diagnostic purposes. Research biopsies underpin hypothesis-driven drug development, pharmacodynamic assessment of molecularly targeted anticancer agents, and, increasingly, genomic assessment for precision medicine; insufficient biopsy specimen quality or quantity therefore compromises the scientific value of a study and the resources devoted to it, as well as each patient's contribution to and potential benefit from a clinical trial.

Methods:

To improve research biopsy specimen quality, we consulted with other translational oncology teams and reviewed current best practices.

Results:

Among the recommendations were improving c

SUBMITTER: Ferry-Galow KV 

PROVIDER: S-EPMC6237512 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature