Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2.

ABSTRACT: Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow (BM) stem cell number/function because of the possible cross-talk between the two organs. This pathological process is accelerated by retinal ischaemia-reperfusion (I/R) injury. This study investigated whether young BM stem cells can regenerate and repair the aged retina after acute I/R injury. Young BM stem cell antigen 1 positive (Sca-1⁺ ) or Sca-1^- cells were transplanted into lethally irradiated aged recipient mice to generate Sca-1⁺ and Sca-1^- chimaeras, respectively. The animals were housed for 3 months to allow the young Sca-1 cells to repopulate in the BM of aged mice. Retinal I/R was then induce

SUBMITTER: Shao Z 

PROVIDER: S-EPMC6237572 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature