A gut microbial factor modulates locomotor behaviour in Drosophila.

ABSTRACT: While research into the biology of animal behaviour has primarily focused on the central nervous system, cues from peripheral tissues and the environment have been implicated in brain development and function¹. There is emerging evidence that bidirectional communication between the gut and the brain affects behaviours including anxiety, cognition, nociception and social interaction^1-9. Coordinated locomotor behaviour is critical for the survival and propagation of animals, and is regulated by internal and external sensory inputs^10,11. However, little is known about how the gut microbiome influences host locomotion, or the molecular and cellular mechanisms involved. Here we report that germ-free status or antibiotic treatment results in hyperactive locomotor

SUBMITTER: Schretter CE 

PROVIDER: S-EPMC6237646 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature