Association between aromatase in human brains and personality traits.

ABSTRACT: Aromatase, an enzyme that converts androgens to estrogens, has been reported to be involved in several brain functions, including synaptic plasticity, neurogenesis, neuroprotection, and regulation of sexual and emotional behaviours in rodents, pathophysiology of Alzheimer's disease and autism spectrum disorders in humans. Aromatase has been reported to be involved in aggressive behaviours in genetically modified mice and in personality traits by genotyping studies on humans. However, no study has investigated the relationship between aromatase in living brains and personality traits including aggression. We performed a positron emission tomography (PET) study in 21 healthy subjects using ¹¹C-cetrozole, which has high selectivity and affinity for aromatase. Before performing PET

SUBMITTER: Takahashi K 

PROVIDER: S-EPMC6237866 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature