Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis.

ABSTRACT:

Objective

To verify the association between the caspase recruitment domain-containing protein 8 (CARD8) single nucleotide polymorphism rs2043211 in the CARD8 gene and cardiovascular diseases.

Methods

A comprehensive search was conducted for related literature in the PubMed, Embase, Cochrane Library, Web of Science, Wanfang Data, and China National Knowledge Infrastructure databases. At last, Six eligible case-control studies were included in this meta-analysis. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between CARD8 rs2043211 polymorphisms and the susceptibility of cardiovascular diseases.

Results

For the homozygous model, OR was 1.21 (1.08-1.36, I2=0.0%, Pheterogeneity=0.542). For the heteroz

SUBMITTER: Huang H 

PROVIDER: S-EPMC6237961 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature