Metagenomic Insights into the Degradation of Resistant Starch by Human Gut Microbiota.

ABSTRACT: Several studies monitoring alterations in the community structure upon resistant starch (RS) interventions are available, although comprehensive function-based analyses are lacking. Recently, a multiomics approach based on 16S rRNA gene sequencing, metaproteomics, and metabolomics on fecal samples from individuals subjected to high and low doses of type 2 RS (RS2; 48 g and 3 g/2,500 kcal, respectively, daily for 2 weeks) in a crossover intervention experiment was performed. In the present study, we did pathway-based metagenomic analyses on samples from a subset of individuals (n = 12) from that study to obtain additional detailed insights into the functional structure at high resolution during RS2 intervention. A mechanistic framework based on obtained results is proposed where prim

SUBMITTER: Vital M 

PROVIDER: S-EPMC6238065 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature