Roux-en-Y gastric bypass surgery alters serum metabolites and fatty acids in patients with morbid obesity.

ABSTRACT:

Aim

Bariatric surgery induces significant weight loss, increases insulin sensitivity, and reduces mortality, but the underlying mechanisms are not clear. It was hypothesized that Roux-en-Y gastric bypass (RYGB) surgery improves metabolic profile along with weight loss. The objective of this pilot study was to evaluate changes in serum metabolites and fatty acids (FA) at 2 weeks and 6 months after RYGB.

Materials and methods

Serum samples were collected pre-surgery, at 2 weeks and 6 months post-surgery from 20 patients undergoing RYGB surgery. Serum non-esterified free FA (NEFA) were measured. Serum metabolites and FA were measured using nuclear magnetic resonance spectroscopy and improved direct fatty acid methyl ester synthesis and the gas chromatography/mass spectrometry m

SUBMITTER: Wijayatunga NN 

PROVIDER: S-EPMC6238211 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature