The severity of LPS induced inflammatory injury is negatively associated with the functional liver mass after LPS injection in rat model.

ABSTRACT:

Background

High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigated. In the present study, the severity of LPS induced inflammatory response was observed after liver resection or portal branch occlusion to decreasing functional liver mass. The local and systemic damage was observed to investigate the role of liver in modulation inflammatory injury.

Methods

First, 30%, 70%, and 90% partial hepatectomy (PH) were performed, and serum TNF-α, survival rate, and hepatic LPS uptake was observed. Second, LPS-exposure of the functional liver mass was decreased by selectively blocking the RL prior to LPS-injection, which was given 30

SUBMITTER: Fang H 

PROVIDER: S-EPMC6238277 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature