Levels of human proteins in plasma associated with acute paediatric malaria.

ABSTRACT:

Background

The intimate interaction between the pathophysiology of the human host and the biology of the Plasmodium falciparum parasite results in a wide spectrum of disease outcomes in malaria. Development of severe disease is associated with a progressively augmented imbalance in pro- and anti-inflammatory responses to high parasite loads and sequestration of parasitized erythrocytes. Although these phenomena collectively constitute common denominators for the wide variety of discrete severe malaria manifestations, the mechanistic rationales behind discrepancies in outcome are poorly understood. Exploration of the human pathophysiological response by variations in protein profiles in plasma presents an excellent opportunity to increase the understanding. This is ultimately requir

SUBMITTER: Reutersward P 

PROVIDER: S-EPMC6238294 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature