MiR-144/451 cluster plays an oncogenic role in esophageal cancer by inhibiting cell invasion.

ABSTRACT:

Background

miRNA clusters are widely expressed across species, accumulating evidence has illustrated that miRNA cluster functioned more efficiently than single miRNA in cancer oncogenesis. It is likely that miRNA clusters are more stable and reliable than individual miRNA to be biomarkers for diagnosis and therapy. We previously found low expression of miR-144/451 was closely related with the risk for esophageal cancer. Researches on miR-144/451 cluster were mostly focused on individual miRNA but not the whole cluster, the regulatory mechanism of miRNA cluster were largely unknown.

Methods

In present study, we firstly analysed biological functions of individual miRNAs of miR-144/451 in ECa9706 transfected with miRNA mimics. We further analysed the biological function of the

SUBMITTER: Gao Z 

PROVIDER: S-EPMC6238332 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature