Mifepristone inhibits non-small cell lung carcinoma cellular escape from DNA damaging cisplatin.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer deaths in the world. The major histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum-based therapy is the standard of care for patients with advanced stage NSCLC. However, even with treatment, most patients will die of this disease within 5 years and most of these deaths are due to recurrence. One strategy to inhibit recurrence is to use cytostatic compounds following courses of lethal chemotherapy. We have shown in various cancer cell types that mifepristone (MF), an anti-progestin/anti-glucocorticoid, is a powerful cytostatic anti-cancer agent. Thus, in this work we tested the hypothesis that MF should be efficacious in inducing cytostasis and preventing repopulation of NSCLC following cispla

SUBMITTER: Kapperman HE 

PROVIDER: S-EPMC6238342 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature