Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma.

ABSTRACT: Activation of the platelet-derived growth factor receptors (PDGFRs) gives rise to some of the most important signaling pathways that regulate mammalian cellular growth, survival, proliferation, and differentiation and their misregulation is common in a variety of diseases. Herein, we present a comprehensive and detailed map of PDGFR signaling pathways assembled from literature and integrate this map in a bioinformatics protocol designed to extract meaningful information from large-scale quantitative proteomics mass spectrometry data. We demonstrate the usefulness of this approach using a new genetically engineered mouse model of PDGFRα-driven glioma. We discovered that acute PDGFRα stimulation differs considerably from chronic receptor activation in the regulation of protein translation in

SUBMITTER: Zhou S 

PROVIDER: S-EPMC6238596 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature