The influence of cell and nanoparticle properties on heating and cell death in a radiofrequency field.

ABSTRACT: The use of non-invasive radiofrequency (RF) energy to induce mild thermal and non-thermal effects in cancer tissue is under study as an adjuvant to chemo, radio or immuno therapy. This study examines cell specific sensitivities to RF exposure and the potential of nanoparticles to elevate heating rates or enhance biological effects. Increases in the heating rate of water in an RF field operating at 13.56MHz (0.004-0.028°C/s) were positively correlated with concentration of hybrid nanoparticles (1-10mg/ml) consisting of water soluble malonodiserinolamide [60]fullerene (C₆₀-ser) conjugated to the surface of mesoporous silica nanoparticles (SiO₂-C₆₀). The heating rate of highly conductive cell culture media (0.024°C/s) was similar to that of the highest concent

SUBMITTER: Mackeyev Y 

PROVIDER: S-EPMC6238638 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature