IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection.

ABSTRACT: Human ascariasis has a global and cosmopolitan distribution, and has been characterized as the most prevalent neglected tropical disease worldwide. The development of a preventive vaccine is highly desirable to complement current measures required for this parasitic infection control and to reduce chronic childhood morbidities. In the present study, we describe the mechanism of protection elicited by a preventive vaccine against ascariasis. Vaccine efficacy was evaluated after immunization with three different Ascaris suum antigen extracts formulated with monophosphoryl lipid A (MPLA) as an adjuvant: crude extract of adult worm (ExAD); crude extract of adult worm cuticle (CUT); and crude extract of infective larvae (L3) (ExL3). Immunogenicity elicited by immunization was assessed by

SUBMITTER: Gazzinelli-Guimaraes AC 

PROVIDER: S-EPMC6238660 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature