Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy.

ABSTRACT:

Background

Our understanding of phenotypic and functional signatures of CD8+ T cell dysfunction in acute myeloid leukemia (AML) is limited. Deciphering these deranged T cell functional states and how they are impacted by induction chemotherapy is essential for incorporation of novel immune-based strategies to restore and maintain antileukemia immunity.

Methods

We utilized high-dimensional immunophenotyping, gene expression, and functional studies to characterize peripheral blood and bone marrow CD8+ T cells in 72 AML patients at diagnosis and after induction chemotherapy.

Results

Our data suggest that multiple aspects of deranged T cell function are operative in AML at diagnosis, with exhaustion and senescence being the dominant processes. Following treatment, the phe

SUBMITTER: Knaus HA 

PROVIDER: S-EPMC6238744 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature