Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice.

ABSTRACT: Cognitive impairments are a common side effect of chemotherapy that often persists long after treatment completion. There are no FDA-approved interventions to treat these cognitive deficits also called 'chemobrain'. We hypothesized that nasal administration of mesenchymal stem cells (MSC) reverses chemobrain. To test this hypothesis, we used a mouse model of cognitive deficits induced by cisplatin that we recently developed. Mice were treated with two cycles of cisplatin followed by nasal administration of MSC. Cisplatin treatment induced deficits in the puzzle box, novel object/place recognition and Y-maze tests, indicating cognitive impairment. Nasal MSC treatment fully reversed these cognitive deficits in males and females. MSC also reversed the cisplatin-induced damage to cortical myel

SUBMITTER: Chiu GS 

PROVIDER: S-EPMC6238972 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature